Most connected single-nucleotide polymorphisms recognized in genome-extensive association research of SLE are in non-coding areas, and thefunctional outcomes For several are mysterious. DNA sequence variants can alter DNA methylation states and gene expression, linking the regulatory genome with individual genetic danger loci. Armed with insights

This paper describes the implementation of genome-large DNA methylation analysis in clinical testing of people with scarce genetic Diseases. It signifies A serious milestone in molecular diagnostics mainly because it innovations medical genetic testing over and above assessment of the DNA nucleotide sequence, or genomics, to clinical epigenomics.